We could restore normal physiology and replace deficient proteins, creating functional cures for patients with chronic diseases, liberating them from constantly needing to worry about their chronic disease and its treatment?
We can combine advanced cell engineering with cutting-edge innovations in biocompatible materials to pioneer a new class of therapeutics, shielded living therapeutics, that provide durable, controllable, and safe treatment for chronic diseases.
Sigilon Therapeutics’ mission is to create immune-protected, engineered human cells that restore normal physiology in a wide range of diseases without generating fibrosis or immune rejection, liberating patients from challenges associated with serious chronic diseases. Treatments based on the Sigilon Therapeutics platform combine advanced cell engineering with cutting-edge innovations in biocompatible materials to pioneer a new class of therapeutics, Shielded Living Therapeutics™ (SLTx), that provide durable, controllable, and safe treatment for serious chronic diseases. In April 2018, Sigilon and Eli Lilly announced a global collaboration to develop encapsulated cell therapies for the potential treatment of type 1 diabetes.
The Shielded Living Therapeutics™ platform combines proprietary Afibromer™ technology with novel, engineereed human cell lines that can produce a wide range of proteins to treat serious chronic disorders.
A New Treatment Modality
For many years, researchers have worked towards implanted cell-based treatments to replace therapies for several chronic diseases. In the case of diabetes, one area of focus has been the development of implanted donor cells that can sense blood glucose and respond by secreting insulin. However, this approach suffers from a critical limitation: a patient’s immune system will recognize donor cells as foreign and then destroy them, unless the treatment is co-administered with immunosuppressant drugs: use of the latter on a long-term basis is associated with significant risks including infection and cancer. This challenge partly explains why cell-based therapeutic implants are not yet more widespread. It also underscores the tremendous potential of Sigilon’s key innovation: The Shielded Living Therapeutics™ platform harnesses the power of therapeutic human cells without inducing an immune response.
These engineered human cells can either deliver proteins at a constant rate or be programmed to respond to changing conditions using the techniques of synthetic biology, such as intermittent flare-ups of disease symptoms (e.g., flare-ups that are characteristic of certain autoimmune diseases) or fluctuating levels of circulating factors such as glucose (e.g., conditions relevant to the treatment of diabetes).
Synthetic biology tools and programmable genetic circuits create new possibilities for the treatment of complex and serious chronic diseases. Shielded Living Therapeutics™ can be programmed to sense changing conditions and respond appropriately, acting as “smart” medicines inside the body. This is unlike gene therapies or RNA interference, which cannot be adjusted once they are introduced into the body.
Sigilon has developed proprietary engineered human cells that are combined with Afibromer™ technology to create effective therapeutics. These human cells:
Express high levels of desired protein(s)
Survive well in an encapsulation environment
Can be produced at large scale
Are like those previously used in clinical applications
Provide the ability to easily insert and remove gene expression cassettes for different applications
In experimental animal models, Shielded Living Therapeutics™ using Afibromer™ technology have resisted fibrosis for 12 months or more. Assuming this success can be repeated in humans, Sigilon’s hope is that Shielded Living Therapeutics™ could generate and secrete the natural biomolecules a patient needs over long periods of time, even years, maintaining constant therapeutic protein replacement. This goes beyond convenience and adherence and is expected to produce superior longer- term patient outcome.
Sigilon’s pipeline of products in hemophilia, lysosomal storage diseases, and, in collaboration with Eli Lilly, type 1 diabetes, are rapidly advancing toward the clinic, and the company is carrying out preclinical studies in other chronic disease indications. The company also believes it will find uses for Afibromer™ beyond cell therapy; for instance, to reduce the incidence of fibrosis when using glass, plastic, or metal in medical implants such as coronary stents.
Latest Press from Sigilon Therapeutics
- Sigilon Therapeutics Expands Intellectual Property Portfolio with New Patent Issued 01.30.2019
- Sigilon Therapeutics and MIT Announce Research Collaboration to Advance Programmable Living Therapeutics for Serious Chronic Diseases 01.07.2019
- Sigilon Therapeutics Announces Appointment of Four New Members of Senior Management Team 11.13.2018
- Sigilon Therapeutics Announces Leadership Transition and Appoints Rare Disease Pioneer Rogerio Vivaldi, M.D., as Chief Executive Officer 08.14.2018
- Sigilon Therapeutics Receives Advanced Therapy Medicinal Product Designation for Afibromer™-Based Living Therapeutic Program 03.08.2018
- Sigilon Therapeutics Appoints David E. Moller, M.D., as Chief Scientific Officer 01.04.2018