Messenger RNA Timeline
Discovery of mRNA
Discovery of interferon induction by mRNA
First in vitro translation of isolated mRNA
Development of liposome-mediated mRNA delivery
In vitro transcription of mRNA
Demonstration that naked mRNA injected into mice is translated
Vasopressin mRNA injected to rat brain corrects disease
First vaccinations with mRNAs encoding cancer antigens
First anti-tumor T cell response after injection of mRNA in vivo
Initiation of first clinical trial with mRNA using ex vivo transfected dendritic cells
Discovery that nucleoside-modified RNA is non-immunogenic
First human cancer immunotherapy using direct injection of mRNA
iPSC generation with mRNA
Nucleoside-modified mRNA corrects disease in preclinical study
Moderna doses first subject in a clinical trial with mRNA investigational medicine
First reports of mRNA-LNP formulation for in vivo vaccines against the Zika virus
Moderna announces dosing of 755 subjects across 10 potential mRNA medicines to treat cancers, influenza, Chikungunya, and respiratory syncytial virus, among other disorders and diseases
Moderna meets its primary efficacy endpoint in the first interim analysis of its COVID-19 vaccine candidate in its Phase 3 study