Foghorn Therapeutics

Foghorn® Therapeutics is discovering and developing a novel class of medicines targeting genetically determined dependencies within the chromatin regulatory system. Through its proprietary scalable Gene Traffic Control® platform, Foghorn is systematically studying, identifying, and validating potential drug targets within the chromatin regulatory system. The Company is developing multiple product candidates in oncology.

The company was co-founded by Cigall Kadoch (Dana Farber Cancer Institute and the Broad Institute), Gerald Crabtree (Stanford and Howard Hughes Medical Institute), and Flagship Pioneering.

Platform

Foghorn is the gene traffic control company. Like the air traffic control system, which coordinates the location, sequence, and timing of airplane traffic, gene traffic control regulates location, sequence, and timing of the factors that control gene expression. The chromatin regulatory system is the cell’s gene traffic control system. Breakdowns in in this system are a major, unexplored cause of cancer and other serious diseases.

Foghorn has a broad proprietary Gene Traffic Control™ product platform based on the biology of the chromatin regulatory system. Foghorn is harnessing the knowledge of this system to develop a new class of drug targets. This approach has revealed previously unrecognized mechanisms responsible for specific cancers and novel therapeutic strategies to treat these diseases. Since its foundation by Flagship Pioneering in 2016, the company has generated new insights into disease, rapidly advanced multiple programs, and built a discovery engine that will simultaneously yield many additional targets.

Foghorn is developing medicines across a range of cancers, exploring applications of gene traffic control in neurology and beyond, and believes that this is just the beginning.