John Pribis joined Flagship Pioneering as an Associate after participating in the firm's 2019 fellowship program. As part of Flagship's team of entrepreneurial scientists, John works across the life cycle of venture creation, including explorations into novel biological mechanisms and biotechnologies, and is closely involved with the conception and development of pioneering start-ups and innovations within the existing Flagship ecosystem.
John earned his Ph.D. in genetics and microbiology at Baylor College of Medicine in the laboratory of Professor Susan Rosenberg, where he studied the evolution of antibiotic resistance. John’s thesis identified a detailed molecular mechanism where antibiotics induce mutagenesis leading to antibiotic resistance in a small sub-population of hypermutating cells. He discovered several compounds that inhibit antibiotic resistance evolution that are being developed further for clinical utility. Prior to joining Flagship, John also worked at the University of Pittsburgh studying trauma immunology and pathogen-host interactions. He discovered several compounds that inhibit sterile inflammation after injury, including one that progressed to clinical trials.
Outside of his work in the lab, John was the founding director of MicroCast, a podcast about real-life microbiology, focused on microbiology education. John was also the co-founder and president of the American Society for Microbiology Texas Medical Center chapter consisting of more than 50 institutions. The organization concentrated on science outreach by hosting lectures, teaching entrepreneurship and patent law, mentoring undergraduates, and teaching middle schoolers about microbes in STEM camps.
In addition to his Ph.D. from Baylor College of Medicine, John also completed post-baccalaureate work in computer science at the University of Pittsburgh, and he holds a B.S. in biosciences from Drexel University. John received the internationally competitive Nat L. Sternberg Thesis prize from Cold Spring Harbor Labs for outstanding Ph.D. work in the field of bacterial molecular biology and the Deborah K. Martin Achievement award from Baylor College of Medicine for outstanding research accomplishment. He has published more than 20 peer-reviewed publications, including articles in the journals Molecular Cell, and Cell. His work has been cited more than 800 times and has been featured in several outlets including Nature Reviews Microbiology and BBC Radio 4.